Aretha Franklin, the music icon and legendary singer known as the "Queen of Soul" during a five-decade career died at home in Detroit on Thursday, her long-time publicist announced. She was 76.
Franklin, who influenced generations of female singers with unforgettable hits including "Respect" (1967), "Natural Woman" (1968) and "I Say a Little Prayer" (1968), died from advanced pancreatic cancer.
The multiple Grammy winner cemented her place in US music history with a powerful, bell-clear voice that stretched over four octaves.
In a career crossing generations, her hits spanned soul and R&B, to gospel and pop.
Franklin passed away at 9:50 am (1350 GMT) surrounded by her family and loved ones, her family said in a statement issued by her publicist.
"It is with deep and profound sadness that we announce the passing of Aretha Louise Franklin, the Queen of Soul," the statement said.
"In one of the darkest moments of our lives, we are not able to find the appropriate words to express the pain in our heart.
"We have lost the matriarch and rock of our family. The love she had for her children, grandchildren, nieces, nephews, and cousins knew no bounds."
Funeral arrangements would be announced in the coming days, the family added, thanking fans around the world for their "incredible outpouring of love" since it first emerged earlier this week that she was gravely ill.
"We have felt your love for Aretha and it brings us comfort to know that her legacy will live on. As we grieve, we ask that you respect our privacy during this difficult time."
The 18-time Grammy award winner inspired multiple singers during her five-decade career from pop diva Mariah Carey and the late Whitney Houston, to Alicia Keys, Beyonce, Mary J. Blige and the late Amy Winehouse.
Franklin was the first woman to be inducted into the Rock and Roll Hall of Fame in 1987.
In 2010, Rolling Stone magazine put her at the top of its list of the 100 greatest singers of all time, male or female.
She sang at the inaugurations of presidents Bill Clinton and Barack Obama.
Clinton and his wife, former secretary of state Hillary Clinton, on Thursday paid tribute to Franklin as "one of America's greatest national treasures".
"For more than 50 years, she stirred our souls. She was elegant, graceful, and utterly uncompromising in her artistry," the former first couple said.
"She will forever be the Queen of Soul and so much more to all who knew her personally and through her music. Our hearts go out to her family and her countless fans," they added.
Singers and musicians quickly flooded social media in mourning her passing, which came on the same day that fellow US music giant Elvis Presley died at his home in Memphis, the city where Franklin was born, 41 years ago.
"I'm sitting in prayer for the wonderful golden spirit Aretha Franklin," Diana Ross tweeted. Singer Annie Lennox called Franklin "simply peerless".
"She has reigned supreme, and will always be held in the highest firmament of stars as the most exceptional vocalist, performer and recording artist the world has ever been privileged to witness," Lennox tweeted.
"Everyone who loved her will be saying little prayers of gratitude, respect and appreciation for the musical life force that enriched our lives."
Franklin — who was widely known by only her first name, in true diva style — rose from singing gospel in her father's church to regularly topping rhythm and blues and pop charts in the 1960s and 1970s.
Beyond "Respect", her powerful cover of the Otis Redding tune that became her calling card, Franklin had dozens of Top 40 singles, according to the Rock and Roll Hall of Fame.
Other hits include "Day Dreaming" (1972), "Jump to It" (1982), "Freeway of Love" (1985), and "A Rose Is Still A Rose" (1998).
A 1986 duet with George Michael, "I Knew You Were Waiting (For Me)", hit number one in several countries.
Franklin's declining health was first disclosed on the Showbiz 411 website late Sunday by Roger Friedman, a reporter and family friend.
He wrote that she was "gravely ill in Detroit. The family is asking for prayers and privacy."
The Detroit News later reported that she was in hospice care, as artistes from across the musical spectrum offered well wishes to the legendary singer who lived in Detroit — the Motor City, home of Motown — most of her life.